Pancreas preparation and process of producing same.



UNITED STATns ATENT FFICEQ IVILIIELM IVEBER, OF STOLBERG II, GERMANY, ASSIGNOR TO CHEMISOHE FABRIK RHENANIA, OF AACHEN, GERMANY.

PANCREAS PREPARATION AND PROCESS OF PRODUCING SAME.

SPECIFICATION forming part of Letters Patent No. 69 5,254, dated March 11, 1902.

Application filed August 28, 1900. Serial No. 28,336. (No specimens.)

To all whom it may concern.-

Be it known that LVVILHELM WEBER, a citizen of Germany, residing at Stolberg II, Rheinland, in the Empire of Germany, have invented a certain new and useful Preparation from the Pancreas and Process of Producing It, (for which application for a patent has been made in Germany, dated April 21, 1900, and in Great Britain, dated August 11, 1900, No. 14,414,) of which the following is a specification.

The enzymes of the pancreatic gland, unlike pepsin, are very sensitive to the action of acids and the juices of the stomach, so that some authorities deem it to be useless to administer paucreatin preparations as inedicaments. By this invention the enzymes of the pancreas are converted into an insoluble form in which they can resist acids and stomach-juices, while they remain freely soluble in alkaline liquids and can then exercise their invention therefore it is possible to make a preparation of pancreas which passes through the stomach unaltered and can exercise its function in the intestines.

The following examples illustrate the in- Vention:

Example I: One hundred grams of pancreatin are stirred into a liter of water and Instead of pancreatin fresh pancreasjuice may be used.

Example 11: The aqueous solution of one hundred grams of pancreatin prepared as described in Example I is made feebly alkaline with normal caustic-soda solution and is mixed with a solution of twenty to twentyfive grams of tannic acid. To the clear liq uid is then added the equivalent proportion of an acid, and the precipitate thus produced is treated like that obtained in Example I.

Having thus described the nature of my said invention and the best means I know of carrying the same into practical effect, I claim- 1. A process for preparing a preparation of pancreas capable of resisting stomach-juices, by mixing a solution containing pancrea'tin with a solution of tannin containing an alkali then adding another acid and then collecting for use the precipitate thus produced.

2. An aseptic composition consisting of one hundred parts of pancreatin chemically com bined with twenty parts of tannin and characterized by insolubility in gastric juice and solubility in intestinal juice.

In testimony whereof I have hereunto set my hand in presence of two subscribing wit nesses.

WVILHELM WEBER.

Witnesses:

J. Soorr, RUDoLn ARNETT. 

